5-Amino-1-mq

5-Amino-1-mq – High-Purity NNMT Inhibitor for Metabolic Research | BioSpark Biotech 

BioSpark (Xi'an) Biotechnology Co., Ltd. proudly supplies 5-Amino-1-mq, a potent and selective small-molecule inhibitor targeting nicotinamide N-methyltransferase (NNMT). With a specification of ≥97% purity verified by HPLC, our product addresses the metabolic decline associated with aging and obesity by restoring intracellular NAD⁺ levels.

The item specifically ties to NNMT with an IC₅₀ of 1.2 μM, diminishing 1-methylnicotinamide (1-MNA) levels (EC₅₀ = 2.3 μM) and improving cellular vitality digestion system. In preclinical considers, it has illustrated about two-fold increments in muscle cross-sectional range and 70% changes in crest torque in matured mice. Furthermore, it diminishes lipid amassing in adipocytes (EC₅₀ = 30 μM), making it exceedingly pertinent for metabolic wellbeing research.

Manufactured by means of chemical union and thoroughly tried for character, virtue, and soundness, our item meets universal quality guidelines counting ISO9001, GMP, FDA, Legitimate, and Halal certifications. Accessible in 1 g, 5 g, and 25 g bundling groups, it's transported by means of cold chain to protect bioactivity.

Why Choose Us?

Choosing BioSpark implies collaborating with a trusted biotechnology pioneer committed to your success.

Expert Detailing & Fabricating: We offer comprehensive OEM and ODM arrangements custom fitted to your venture needs. From equation optimization to versatile generation, our group bolsters you at each stage.

Rigorous Quality Affirmation: Each bunch experiences multi-point testing counting HPLC virtue profiling, ESI-MS character confirmation, GC remaining dissolvable examination, ICP-MS overwhelming metal screening, and quickened solidness considers. You get items that meet the most elevated inquire about standards.

Global Reach & Unwavering quality: Our items are trusted over Europe, North America, South America, Southeast Asia, and the Center East. We guarantee opportune conveyance with adaptable shipping terms (Coxcomb, CIF, CFR, EXW, DAP, DDP) and secure cold chain logistics.

Customer-Centric Benefit: Whether you require small-batch customization or large-scale orders, we give adaptable MOQs beginning at fair 1 g. Our committed group is continuously prepared to help with specialized request and after-sales support.

Specification

Certificate of Analysis (COA)

Each batch of 5-Amino-1-mq is accompanied by a comprehensive COA detailing:

• Purity Analysis: HPLC confirmation of ≥97% purity with total impurities <2%
• Identity Confirmation: ESI-MS molecular mass verification
• Residual Solvents: GC testing per USP <467> limits
• Heavy Metals: ICP-MS screening for lead, arsenic, mercury, and cadmium at ppb levels
• Microbial Testing: Compliance with sterility standards
• Moisture Content & Residue on Ignition: Within specified limits

This transparency ensures you receive consistent, reliable material for your research or formulation projects.

Certifications

BioSpark holds multiple internationally recognized certifications:

• ISO9001: Quality management systems
• GMP: Good Manufacturing Practice compliance
• FDA Registration: Regulatory compliance for U.S. markets
• Kosher & Halal: Meeting dietary and ethical standards
• Laboratory Accreditation: Advanced testing capabilities

  

These credentials reflect our commitment to safety, quality, and regulatory excellence.

Benefits of 5-Amino-1-mq

Supports Metabolic Wellbeing: By restraining NNMT, this compound increments intracellular NAD⁺ levels, advancing mitochondrial biogenesis and vitality digestion system. It decreases lipid aggregation and has appeared adequacy in diet-induced weight models.

Promotes Muscle Recovery: In vivo considers illustrate that it salvages maturing muscle stem cell movement, essentially expanding muscle fiber recovery and crest torque—ideal for anti-aging and sports nourishment research.

Anti-Aging Impacts: Tweaking the NAD⁺ rescue pathway makes a difference check age-related metabolic decay, supporting cellular essentialness and life span research.

Favorable Security Profile: Creature considers at dosages up to 60 mg/kg/d appeared no unfavorable impacts, showing solid tolerability.

Cell-Permeable & Strong: With an IC₅₀ of 1.2 μM, it offers tall selectivity and adequacy, making it a effective device for researchers.

Application Areas

5-Amino-1-mq is widely applied across multiple research and product development fields:

• Anti-Aging Items: Tending to sarcopenia and geriatric health
• Metabolic Wellbeing Definitions: Overseeing weight and diabetes research
• Sports Sustenance: Muscle damage repair and execution enhancement
• Oncology Inquire about: Adjunctive considers in cancer treatment (illustrated adequacy in ovarian cancer models at 20 mg/kg/d)
• Research Reagents: Devices for examining NNMT protein action and cellular metabolism
• Pharmaceutical Advancement: Crude fabric for novel small-molecule medicate development

Please note: This item is expecting exclusively for investigate purposes and has not been affirmed for human restorative utilize. It must be taken care of beneath qualified proficient guidance.

Quality Control

Quality control is the foundation of our operations. Each group of the item experiences thorough inspection:

1. Virtue Profile: HPLC testing guarantees add up to pollutions stay underneath 2%, ensuring research-grade material.

2. Character Confirmation: ESI-MS affirms correct atomic mass, avoiding mix-ups or contamination.

3. Leftover Dissolvable Examination: GC examination guarantees solvents like DMSO and methanol comply with USP limits, ensuring your exploratory integrity.

4. Overwhelming Metal Screening: ICP-MS identifies lead, arsenic, mercury, and cadmium at ppb levels, guaranteeing security for touchy applications.

5. Solidness Testing: Quickened debasement ponders decide shelf-life beneath different conditions, affirming the particle remains dynamic and non-degraded all through storage.

This comprehensive approach ensures you get a steady, unadulterated, and solid item each time.

R&D Results

Our in-house R&D group persistently refines generation and detailing forms to maximize item viability and stability.

Advanced Refinement: Chosen high-purity unrefined fabric experiences pretreatment, preparative HPLC filtration utilizing C18 reversed-phase columns, and angle elution with water-acetonitrile (0.1% formic corrosive). Target components are collected, solvent-recovered, and vacuum freeze-dried to protect solidness and bioactivity.

Micronization & Sterilization: The dried powder is micronized and sieved for uniform molecule measure, at that point sterilized and thoroughly tried for virtue ≥98%, dampness substance, and microbial defilement some time recently airtight sealing.

Preclinical Approval: Creature considers affirm adequacy in muscle recovery, metabolic wellbeing, and anti-tumor movement, giving strong information for your investigate applications.

Packaging and Transportation

We prioritize item astuteness from our office to your lab.

Packaging Choices: Accessible in 1 g/bottle, 5 g/bottle, and 25 g/drum designs to suit different venture scales.

Storage Conditions: Hermetically fixed and put away at -20°C beneath cool, dry, and light-protected conditions to keep up stability.

Shipping Strategies: Cold chain express and discuss cargo guarantee temperature-controlled conveyance, protecting bioactivity amid transit.

Delivery Terms: Adaptable choices counting Dandy, CIF, CFR, EXW, DAP, and DDP to meet your calculated preferences.

After-Sales Service

Your fulfillment is our need. BioSpark offers comprehensive after-sales support:

• Technical Meeting: Our specialists are accessible to reply questions almost item dealing with, capacity, and application.
• Documentation Back: Get to to COAs, MSDSs, and administrative documentation upon request.
• Custom Arrangements: Require a particular detailing or bundling? We give adaptable OEM/ODM administrations custom-made to your requirements.
• Reliable Communication: Provoke reactions to request guarantee smooth extend progression.

We're committed to building long-term associations based on believe, quality, and shared success.

FAQ

Q1: What is the least arrange quantity?

A1: Our MOQ is fair 1 g, making it available for starting inquire about trials or small-scale projects.

Q2: How is purity verified?

A2: Purity is confirmed via HPLC, with each batch accompanied by a COA detailing ≥97% purity and total impurities <2%.

Q3: Can I utilize this item for human consumption?

A3: No. This item is expecting exclusively for inquire about purposes and has not been affirmed for restorative utilize in humans.

Q4: What are the capacity requirements?

A4: Store at -20°C in a cool, dry, light-protected environment. Handle concurring to MSDS guidelines.

Q5: Do you offer custom formulations?

A5: Yes. We give comprehensive OEM and ODM administrations, counting equation advancement, bundling plan, and versatile production.

Q6: What installment strategies do you accept?

A6: Wire exchange (T/T) is favored, with adaptable terms accessible for set up clients.

Q7: How long does shipping take?

A7: Conveyance times change by goal and shipping strategy. Cold chain express guarantees quick, temperature-controlled transit.

Q8: Are universal certifications available?

A8: Yes. We hold ISO9001, GMP, FDA, Legitimate, and Halal certifications, supporting worldwide advertise get to.

Contact Us

Ready to elevate your research or product development with 5-Amino-1-mq? Reach out to BioSpark today for inquiries, quotes, or custom solutions. Email us at sales@biosparkcn.com and let's achieve your goals together.